The Reds Devils are unbeaten against their Merseyside rivals in the last the six league matches, but were dumped out of the Europa League by Jurgen Klopp’s side in 2016.
Mata knows his team will be in for a hostile reception when they arrive for the early kick-off.
But he says that football would not be the same if the crowds were tamed and he is buzzing for the occasion.
“It’s tough,” Mata told Sky Sports. “It’s a tough atmosphere. Obviously, the stadium is full of supporters wanting their team to go over us and win. That’s what makes football special.
“Not speaking about violence at all, but about the atmosphere. You have to have personality to play in these games.
“If we manage to impose ourselves in the game to control the emotions from the crowd, and play good football, I think we have a chance to win.”
The 29-year-old has also been helping with the launch of charity Common Goal, in which footballers opt to donate one per-cent of their salaries to the cause.
Juventus’ experienced defender Giorgio Chiellini has also signed up to the charity, and Mata says there will be more names announced in the coming weeks.
“It’s been great,” Mata said. “It’s a really inspiring movement and project.
“It’s nice to see how football has welcomed it, some fellow players and media, and people that make decisions in football.
“I have [received a lot of interest from players]. We have announced many players, and still have many players to announce in the coming weeks.
“The reception has been great and I’m really thrilled about what Common Goal means for so many people.
“I think something like this was needed. We are privileged people, we are in a lucky position, and so many people in the world are not as lucky as us.”