The Saracen was yesterday axed by coach Eddie Jones after England’s patchy performance against Argentina last weekend.
Kruis’s exclusion paves the way for a possible recall for the rested Maro Itoje, although Jones also has the option of promoting Joe Launchbury from the bench or turning to Bath’s Charlie Ewels, who was named in a 25-man squad as well last night.
Owen Farrell also looks poised to return with the unfortunate Alex Lozowski, one of England’s few bright sparks against Argentina, released back to Saracens.
Lions prop Joe Marler will definitely be involved after returning from a three-week suspension.
The Harlequins prop was named in the squad with Ellis Genge, a replacement against the Pumas, sent back to Leicester for Sunday’s Premiership game against Sale.
Jonny May is also set to feature after shaking off a hamstring issue.